We don't have that many options, but it ultimatly depends on how much mana you need. If you never run out of mana(some acid or have-luck-healer builds) use a 1-handed weapon (dagger) and a second hand item to increase resistances. If you play a vamp-a-like build you will definitly need the mana, so a weapon with high faith(2h Spear or Staff) might suit you.